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Neuroinflammation disrupts the neuronal microenvironment, interfering with drug action and accelerating the aggregation of alpha-synuclein 73

doi: 10.1093/biolre/ioz187

Additionally, simvastatin is also highly lipophilic and can cross the bloodbrain barrier

In this regard, fabrication of azelaic acid nanocrystals dispersed in Pluronic F127 and hyaluronic acid was accompanied by enhanced solubility, dissolution rate, drug stability, and skin permeability (Tomi et al., 2019b)

Methotrexate selectively targets human proinflammatory macrophages through a thymidylate synthase/p53 axis
