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Furthermore, a study on neuronal cells in vitro has shown a certain level of high K + environment triggers membrane depolarization, which in turn leads to a sustained expression of neurexin-1-SS4+ and a reduction in neuronal neurexin-1-SS4- expression, an effect that occurs in astrocytes and even in neuronal cell injury, which inevitably affects synaptic plasticity [81]

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Yeung KS, Hernandez M, Mao JJ, Haviland I, Gubili J