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J.MirandaM.RomeroF

In agreement with previous studies, , we observed that MgSO, alone and with DZP, was able to attenuate these nicotine-induced changes in oxidative stress parameters

304 Importantly, mitochondrial dysfunction also alters mTORC1 activity, primarily through reduced oxidative phosphorylation, which lowers ATP production and increases the AMP/ATP ratio, activating AMPK, which phosphorylates TSC2 and RAPTOR, leading to mTORC1 inhibition and a shift toward energy conservation and stress adaptation

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For example, Fox et al

The system automatically aligns annotation information from databases such as Kyoto Encyclopedia of Genes and Genomes (KEGG) and UniProt, generating a comprehensive analysis report that includes GO entries, enrichment factors, P-values, and False Discovery Rate (FDR) values