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For example, dysregulated IGF signaling is thought to contribute to an imbalance between cancer stem-cell self-renewal and differentiation, resulting in the development of non-differentiated cells with stem cell-like properties, and subsequent malignant transformation [29]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Yang M., Wang Y

Hirota K, Murata M, Sachi Y, Nakamura H, Takeuchi J, Mori K, et al

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Blachier, F., Beaumont, M
