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However, the effectiveness of integrating these agents into exercise prescriptions for MM patients remains to be validated (Figure 6) ( Figure 6 In addition to clinical observations in MM patients, several pharmacological strategies have also been investigated in experimental MM mouse models to explore their potential effects on mitochondrial function and muscle performance (101103)

Moreover, OHB has been shown to improve the resistance to oxidative stress (Wei et al., 2014

Activated TGF-RI then recruits and phosphorylates the downstream signaling molecules SMAD family members SMAD2 and/or SMAD3, which subsequently combine with SMAD4 to form a heterotrimeric complex

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J Morphol 250: 197207, 2001

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