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The influence of ketogenic therapy on the 5 Rs of radiobiology

2022;11(4):788.[DOI] 141

However, treatments based on splitting alone have struggled to produce clinically meaningful outcomes

doi: 10.1016/j.biopha.2023.115431

Beyond DHFR inhibition, MTX and the polyglutamate forms impede de novo purine synthesis and thymidylate synthase, intensifying the cytotoxic effects that affect cell proliferation and growth ( Despite the efficacy of MTX, related toxicity has been reported in several studies, including liver toxicity (increase of liver function, risk of liver failure), kidney toxicity (renal impairment, renal failure), hematological toxicity (pancytopenia, myelosuppression, leukopenia, neutropenia, megaloblastic anemia), pulmonary toxicity (wheezing, asthma), dermatological toxicity (skin lesion), and gastrointestinal (GI) effects (diarrhea, nausea, vomiting, etc

The convergence of these factors has created an optimal environment for the emergence of accessible, physician-supervised injectable glutathione programs like those offered by ReadyRx