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Indeed, astrocytes seem to be heavily involved in the dopaminergic reward system (Corkrum et al., 2020)

2021 Feb;31 (2):107-125

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Thus, it can be that the general NO-system significance goes against the mentioned specific NO-agent drawbacks and against the current lack of suited NO-related therapy to specify and resolve given etiopathology [124,125]

Many clinical nutritionists recommend taking both for comprehensive support