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PANC-1 cancer stem-like cell death with silybin encapsulated in polymersomes and deregulation of stemness-related miRNAs and their potential targets

[DOI] [PubMed] [Google Scholar] 165.Chen Y., Zhu B., Zhang H., Liu X., Guo S.W

[DOI] [PMC free article] [PubMed] [Google Scholar] 60.Imai Y., Kuba K., Neely G.G., Yaghubian-Malhami R., Perkmann T., van Loo G., Ermolaeva M., Veldhuizen R., Leung Y.H., Wang H., et al

This severe glutathione deficit was accompanied by elevated ventricular lactate, a clear biomarker indicating that the brains of these patients are relying on highly inefficient, oxygen-deprived anaerobic metabolism due to mitochondrial stress

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This indicates that the unnatural stereochemistry on the N-terminal and cysteineglutamic acid peptide bond can interfere with GGT activity [32]