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However, the role of ketones in glioma becomes complex, as previous research indicates that glioma cells cannot metabolize ketone bodies like normal neural tissue, making the role of ketogenesis in glioma progression unclear [128, 129]

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These processes have been demonstrated to exhibit dual characteristics in cancer biology, either promoting or suppressing tumor development based on variables such as the TME, genetic changes, and metabolic context (Sever and Brugge 2015

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