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p66Shc, oxidative stress and aging: Importing a lifespan determinant into mitochondria

Breakthrough compound for mitochondrial function studies

The TCA cycle is not only involved in catabolism, but is also critical for the biosynthesis of a number of molecules including amino acids, lipids, and nucleotide bases (Roberts et al., 1953)

Unlike traditional peptides, MOTS-c directly influences cellular metabolism by enhancing glucose uptake, increasing fatty acid oxidation, and supporting mitochondrial function

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