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Afterwards, the cells were centrifuged (20,000 g, 10 min), washed with 1 PBS, re-counted, and adjusted to 4 10 5 yeast cells/mL in the respective medium

E., Lepicard, E

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For patients who were originally in the placebo group whose cancer began to progress during the study, doctors permitted a switch to vorasidenib

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Collectively, these analyses indicate that effective dual PDE1B/PDE10A inhibitors will require finely tuned physicochemical properties, strong metabolic stability, and minimal efflux liability to achieve sustained brain exposure with adequate selectivity