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M.TarantinoE.De CaroA

Inverse data-driven modeling and multiomics analysis reveals phgdh as a metabolic checkpoint of macrophage polarization and proliferation

Key Benefits Enhanced protein synthesis and nitrogen retention support muscle growth and preservation, even during caloric restriction

Intestine-specific metabolic processes are also essential for hormone regulation, particularly incretin hormones, which enhance glucose homeostasis

The underlying molecular mechanisms involve direct ROS-induced oxidative damage to neuronal lipids, proteins and DNA [331], as well as ROS-mediated oxidative modifications that crucially promote the aberrant aggregation of toxic proteins [332]

doi: 10.3389/fimmu.2021.645242