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the compound of formula (I) is selected from the group consisting of: the presently disclosed subject matter provides a pharmaceutical composition a pharmaceutical composition comprising a compound of formula (I) and a pharmaceutically acceptable carrier

1998), but not in rat enterocytes (Coloso and Stipanuk 1989) or rat renal cortical tubules (Stipanuk et al

10.1155/2022/8796735 Oxid Med Cell Longev

More than 80-90% of total ROS are reportedly generated by mitochondrial electron chain Complexes I and III, and NADPH after oxidation by NOXs (NADPH oxidases) is another important source of O 2 - and H 2 O 2 producing-proteins in signal transduction[75, 76]

Moreover, the detection of elevated H 2 O 2 levels in colonic epithelial cells prior to the onset of colitis fulfills the absolute criterion of temporality required to establish a cause-and-effect relationship between H 2 O 2 (the cause), which must be present before UC (the effect)

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