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Post-mortem studies and patient-derived models consistently show features of mitochondrial dysfunction, such as swelling, fragmentation, and vacuolization, particularly in motor neurons [197,198,199,200]

[PubMed 8697030] 1994

Functional studies using conditional STAT 1 knockout mice have shown that keratinocyte-derived chemokines and IFN- signaling drive vitiligo and proper homing of auto-reactive T cells to the epidermis

P140 peptide leads to clearance of autoreactive lymphocytes and normalizes immune response in lupus-prone mice

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