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Together, these limitations reveal a fundamental weakness in the translational pipeline: Preclinical models, often biologically reductionist and poorly representative of human pathology, remain inadequate to support the development of interventions with reproducible and clinically relevant neuroprotective effects

The safety and efficacy of ivermectin lotion have not been established in neonates or infants = 1 g/day PO), can cause adverse reactions more frequently

Designed for use as a diluent, it allows for safe and repeated withdrawal from the same vial

This is a phenomenon known as tolerance

The effect is particularly noticeable in poorly vascularized tissues like tendons, which normally heal slowly due to limited blood flow

The role of PDI in SARS-CoV-2 infection could be experimentally verified by performing binding assays between SARS-CoV-2 spike and ACE2 receptor proteins under oxidative stress in the absence and presence of PDI