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Under conditions of compromised mitochondrial function, the PMF falls below the threshold required for ATP synthesis and the activity of ATP synthase can actually reverse such that it hydrolyzes ATP to pump protons back into the inner membrane space

2017 Jul 1;5(2):261-8

A study analyzing 530 COVID-19 deaths in seven Greek hospitals in Athens from January to August 2022 found that only 25.1% were directly caused by COVID-19, with 29.6% involving the coronavirus as a contributing factor, while 45.3% of deaths among patients who tested positive for SARS-CoV-2 were unrelated to the virus

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Metabolism of dietary and microbial vitamin B family in the regulation of host immunity