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-GCS first ligates the -carboxyl group of L-glutamate (Glu) to the amino group of L-cysteine (Cys), which results in the production of L--glutamyl-L-cysteine (-Glu-Cys) [3]

tRNA Ligase Is Required for Regulated mRNA Splicing in the Unfolded Protein Response

This, in turn, would drive oxidatively induced cell death and increase barrier dysfunction and T2 inflammation, potentially identifying a mechanism by which viruses cause asthma exacerbations

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Insights into the pathogenesis of neurodegenerative diseases: focus on mitochondrial dysfunction and oxidative stress

Inhibition of TMEM16A by natural product silibinin: potential lead compounds for treatment of lung adenocarcinoma