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Gene therapy is emerging as a pioneering field, targeting curative outcomes by altering the genetic framework underlying DR

Achieving optimal long-term glycemic control as well as reducing the risk of cardiovascular (CV), neurodegenerative diseases, and mortality continues to be a challenge for a significant portion of patients with type 2 diabetes (T2DM) and type 1 diabetes (T1DM) worldwide [8,9,10,11,12,13,14]

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If it is sliced from the membrane, TNF becomes a soluble form (solTNF) that mainly binds to TNF receptor 1 (TNFR1: CD120a or p55/p60) [88]

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