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The rs1805008 variant, commonly known as R160W, is one of the best-characterized reduced-function MC1R variants and has been strongly associated with lighter pigmentation traits, reduced tanning capacity, and altered melanocortin responsiveness

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Lephart ED, Adlercreutz H, Lund TD (2001) Dietary soy phytoestrogen effects on brain structure and aromatase in Long-Evans rats

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