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Increased signaling through exchange proteins directly activated by cAMP (EPACs), specifically EPAC2, and activation of protein kinase A (PKA) follow the rise in cAMP

Chem 281 (44) (2006) 3310733114

The GLS inhibitor CB-839/telaglenastat was tested in several clinical trials in solid tumors [167,168,169]

Science China Life Sciences 58 (5), 509511

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