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When vitamin B12 levels are too low, the production of red blood cells is altered, causing megaloblastic anemia

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This preservation of GPX4 maintained its ability to reduce lipid hydroperoxides using GSH as a co-substrate

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The oxidation of Cys thiols leads to the formation of sulfenic acid (RSOH), which can react with other reactive sulfur species to form mixed disulfides (RSSR) with protein thiols, S -glutathione adducts (RSSG) with glutathione, or persulfides (RSSH) with hydrogen sulfide (Willems et al