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Manji, H

While short-term use may cause only transient effects, prolonged supraphysiological IGF-1 receptor activation could potentially cause unwanted tissue growth including cardiac hypertrophy, which at extreme levels could impair cardiac function, and growth of other organs

Zinc deficiency leads to a significant decrease in the activity of enzymes in the reproductive tract of male animals

Cell Metabolism

A later study found that RSV infection down-regulates NRF2 expression in airway epithelial cells and a decrease in the expression of airway antioxidant enzymes led to additional oxidative stress

Andrographolide-loaded solid lipid nanoparticles enhance anti-cancer activity against head and neck cancer and precancerous cells