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That framing is risky

[DOI] [PubMed] [Google Scholar] 37.Rosenstock J, Allison D, Birkenfeld AL, et al

Hydration and electrolyte management Diarrhea causes dehydration

Patients with specific genetic predispositions may respond better to tirzepatide, a dual GIP/GLP-1 receptor agonist offering 20% greater weight loss than semaglutide monotherapy in clinical studies

If you suspect your vial froze, do not use it

These can lead to dehydration and electrolyte imbalances, which commonly cause fatigue
