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Another route through which CLOCK and BMAL1 can function is by promoting the transcription of the nuclear receptors REV-ERB [also known as NR1D1 (nuclear receptor subfamily 1 group D member 1)] and ROR, which is one of melatonins target receptors

A characterization of white matter pathology following spinal cord compression injury in the rat

doi: 10.1016/j.jmr.2018.05.005

132 MelaV.HerasV.IesmantaiteM.Garca-MartnM
doi: 10.1136/jnnp-2018-320050

Interestingly rats given p53 inhibitors and amifostine did not have improved survival compared to controls, suggesting amifostine acts (at least in part) via a p53 dependent mechanism [55]