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The system Xc, a dimer consisting of SLC7A11 and SLC3A2, exchanges glutamate (Glu) out of the cell and cystine into the cell at a ratio of 1:1 [27, 28]

Results showed that administration of NAC increased levels of GSH and reduced levels of endothelial adhesion molecules and could prevent vascular damage in patients with diabetes [149]

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The harsh GI environment promotes enzymatic degradation and poor absorption, necessitating subcutaneous injections, which compromise patient adherence

Therefore, innovative strategies targeting these specific mechanisms are needed to improve the efficacy and tolerability of ADCs in autoimmune diseases

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