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Description
When NNMT is inhibited by compounds like 5-Amino-1MQ, more nicotinamide becomes available for conversion to NAD+ via NAMPT
The metabolism boost helps people lose pounds if they follow a strict diet

It is typically administered by a healthcare professional in a clinic or hospital, but in some situations, patients may need to administer this medication in the home environment
By inhibiting NNMT, the compound preserves the nicotinamide pool, allowing the salvage pathway to maintain higher NAD+ levels without external supplementation

Peter Attia MD

In diet-induced obese (DIO) mouse models, NNMT inhibition led to approximately 35% reduction in white adipose tissue mass compared to controls