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[Google Scholar] 227.Coelho L.F., Bolner de Lima C.J., Bernardo M.P., Alvarez G.M., Contiero J

Avoid Smoking and Alcohol: These can deplete antioxidants in the body and reduce the effectiveness of glutathione

The excess ROS, including superoxide anion (O 2 ), singlet oxygen ( 1 O 2 ), hydrogen peroxide (H 2 O 2 ), hydroxyl radical (OH), and so on, would induce oxidative damage to biomolecules (e.g., proteins, lipids, and DNA) and, thus, lead to severe cellular damage ( 2 (Rothenberg et al., 2003), CP of 350 mg/m 2 (Krarup-Hansen et al., 2007)] and can be characterized by sensory neurotoxicity (e.g., sensation loss and changes) due to the accumulation of Pt drugs at the peripheral nervous system ( To solve the challenge, numerous researchers devote to exploring the mechanism of PIPN, which are principally implicated in transporter overexpression (Sprowl et al., 2013), ROS upregulation (Leo et al., 2020), ion channel dysfunction (Janes et al., 2015), and so on

Persistent inflammatory responses driven by DNA damage, ER stress, and autophagy disruption contribute to cellular senescence, tissue fibrosis, and possible transgenerational effects [12]