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Symptoms such as persistent fatigue, neurological symptoms, or glossitis should prompt medical review

doi: 10.3389/fnagi.2026.1835649 Received 21 March 2026 Revised 04 May 2026 Accepted 07 May 2026 Published 29 May 2026 Volume 18 - 2026 Edited by Ruosha Lai, Central South University, China Reviewed by Qingwei Ruan, Fudan University, China Emily Fabrizio-Stover, Medical University of South Carolina, United States Updates Copyright 2026 Liu and Liu

Retatrutide is an investigational peptide that activates GLP-1, GIP and glucagon receptors to reduce appetite, increase feelings of fullness and improve metabolic function

Gln deprivation suppresses GOT2-mediated aKG production, and the decreased aKG level results in inhibition of the KDM4C-mediated promotion of cFLIP transcription, which increases the sensitivity of PDAC cells to TRAIL

Constipation is the most common gastrointestinal dysfunction in PD

Adverse reactions are further categorized by body system and listed in order of decreasing frequency according to the following definitions: Frequent -adverse reactions occurring in at least 1/100 patients (1% of patients) (only those not already listed in the tabulated results from placebo-controlled trials appear in this listing)