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Methionine deprivation induces a targetable vulnerability in triple-negative breast cancer cells by enhancing TRAIL Receptor-2 expression

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Yang L., Gilbertsen A., Smith K., Xia H., Higgins L., Guerrero C., Henke C

This is associated with the inhibition of the activation of the toll-like receptor 4 (TLR4) signaling pathway and the expression of COX-2 and nitric oxide synthase 2(84)

For IP, the following antibodies were employed: monoclonal mouse anti-HA (16B12) (901518, BioLegend, Koblenz, Germany)

Altogether, our data show that DJ1 loss of function reduces lysosomal capacity, resulting in the accumulation of toxic forms of synuclein and increased neuronal cell death