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HCV is characterized by a high mutation rate and considerable genomic heterogeneity, which have consequences for the effectiveness of treatment.4 Genotype identification is important clinically because genotypes 1 and 4 are more resistant than are genotypes 2 and 3 to Pegylated interferon and Ribavirin combination therapy, and thus require different treatment duration and dose

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In the presence of wild-type PGL-1::SNAP, all three proteins, PGL-1, PGL-3 and GLH-1, colocalized to granules at the nuclear periphery (Fig

S., Benard, C

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