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Description
The diversity of indications for which (in)GSH is being prescribed warrants separate discussions of clinical significance, so the three primary indications will be discussed separately below

Statements Author contributions JQ and ZY guided the scope and research background of the research, and wrote the manuscript

What Is SMART

These redox imbalances also impact astrocytes, which normally synthesize GSH through the consecutive sections of two ATP consuming cytosolic enzymes

In addition, a meta-analysis of studies of cancer patients treated with cisplatin found that ACYP2 rs1872328, which plays a role in calcium homeostasis, increased the risk of ototoxicity 4.6-fold (95% CI: 3.07.0), and LRP2 rs4668123 increased the risk of ototoxicity 3.5-fold (95% CI: 1.58.5) (144)

Similarly, combination therapy with ginkgo biloba extract and haloperidol has been reported to achieve better efficacy, enhancing the effectiveness of antipsychotics and reducing some extrapyramidal side effects (44)
