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These barriers contribute to a massive economic burden, with the pharmaceutical industry losing an estimated $50 billion annually due to ineffective formulations

However, recent sophisticated research has provided pharmacogenetic insights into the neurogenetic mechanisms of opioid-induced analgesia (Figure 6)

[DOI] [PMC free article] [PubMed] [Google Scholar] 31.Rahman I., MacNee W

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Previous studies have also demonstrated that transgenic plants overexpressing OLP are tolerant to other stress factors such as salt, drought, cold, and bacterial and fungal pathogens 42,43,44,45,46,47,48