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49 Finally, one study reported the prevalence of seven abnormal mitochondrial histological findings, but it was unclear from the study how many children had more than one abnormal finding, and therefore the prevalence of each finding could not be calculated nor included in the analysis

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doi: 10.1007/s00420-013-0863-z

Reguzova A, Mller M, Pagallies F, Burri D, Salomon F, Rziha HJ, Bittner-Schrader Z, Verstrepen BE, Bszrmnyi KP, Verschoor EJ, Gerhauser I, Elbers K, Esen M, Manenti A, Monti M, Rammensee HG, Derouazi M, Lffler MW, Amann R

Since then, MTHFR and other folate-related gene variants have been implicated in a wide array of multifactorial disorders, including cardiovascular disease, cancer, psychiatric illness, and reproductive complications (see Figure 1 )