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10.3748/wjg.v20.i44.16639 World J

China Foreign Medical Treatment

BPC-157: After being administered to clinical models during trials, it may modulate multiple pathways

22, the G/D-CuP group showed a significantly lower proportion of CD86-positive cells compared to the negative control (NC) group

This is often measured by an increase in alpha wave production in the brain, which was illustrated in a study looking at L-theanines relaxation potential after 40 minutes of administration in a dose range of 50-200mg.13 A systematic review of L-theanine specifically studied for sleep declared that a range of 50-655mg could improve sleep onset latency, total sleep time, sleep efficiency, overall sleep quality, and next-day alertness.17 Neurological health (including memory and attention) Animal studies have shown that L-theanine can cross the blood-brain barrier through both oral and intravenous administration.18 19 Once there, in addition to its calming effect, L-theanine has been shown to improve recognition and recall scores in patients with mild cognitive impairment at as little as 60mg/day.20 It was also shown to improve attention and reaction time in subjects at 200mg/day on its own or combined with 160mg of caffeine.5 21 Longevity There is limited human evidence looking at L-theanine in isolation, but animal studies have shown a small increase in average lifespan and maximum lifespan with L-theanine supplementation.22 And a cohort study looking at participants with constant tea consumption status found that tea consumption effectively slowed biological aging.23 More direct human research is needed, but these results are promising

This is especially important for biologics that can cross the blood-brain barrier to effectively control inflammatory injury and mitigate the corresponding deleterious effects on the brain and peripheral tissues