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Copper can reach levels 6 times higher in e-cigarette aerosol than those reported for conventional cigarette smoke 71 , and has been shown to change CTR1 and ATP7A protein levels by post-transcriptional regulatory mechanisms 72,73

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Regular nicotine consumption may worsen stress, depression, and anxiety

Nat Rev Cardiol 18(8):547564 Wang JB, Olgin JE, Nah G, Vittinghoff E, Cataldo JK, Pletcher MJ et al (2018) Cigarette and e-cigarette dual use and risk of cardiopulmonary symptoms in the Health eHeart Study