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In PD, impaired autophagy disrupts lysosome-dependent degradation, hindering the clearance of damaged organelles (Lizama and Chu 2021)
Additionally, Zhu et al
In these mice, reduced expression of Sirt6 is accompanied by significant activation of Nrf2/HO-1 as downstream targets of Sirt6
10.1080/00498254.2022.2048323 147 ShiL.LiD.KangW
[32] Weiduschat, N., Mao, X., Hupf, J., Armstrong, N., Kang, G., Lange, D.J
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