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Emerging research in pharmacogenomics, pharmacokinetics, and pharmacodynamics shows that genetic variants (CYP enzymes, receptor genes like GLP1R, metabolic pathways like COMT and UGT1A1), combined with individual differences in metabolism, body composition, and hormonal baseline, influence how people respond to specific peptides

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Mol Gen Genomics 272:639650 Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-DeltaC(T)) method