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One important factor influencing the efficacy of intra-articular drugs is their residence time within the joint

Antioxidants (Basel, Switzerland), 10(6), 967

Pan Z, Yin H, Wang S, Xiong G, Yin Z (2020) Bcl-xL expression following articular cartilage injury and its effects on the biological function of chondrocytes
Antioxidants are the eliminators and detoxifiers of the free radicals in your body

[DOI] [PubMed] [Google Scholar] Yamaguchi T, Sano K, Takakura K, Saito I, Shinohara Y, Asano T, Yasuhara H

Gastrointestinal effects dominate the side effect profile