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28,29 Therefore, a final goal of this perspective is to discuss the possibility that environmental and endogenous aldehydes can interact additively and thereby amplify cellular oxidative damage associated with many pathogenic and toxicogenic processes

Compromised anti-ferroptosis defense in SOD1 G93A mice and ALS patient samples Because of Gpx4s unique role in reducing lipid hydroperoxides to suppress lipid peroxidation and regulate ferroptosis, we were also interested in determining the status of Gpx4 in SOD1 G93A mice

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The entire model was checked manually and regions of weak or unclear density were modelled as polyalanine