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Conversely, hyperglycemia contributes to the genesis of advanced glycation end products (AGEs), oxidative stress, and inflammation, thereby exacerbating cardiac dysfunction and provoking structural remodeling [612]

Inhibition of ferroptosis by GPx4 provides protective mechanisms against neurodegeneration

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Additionally, Fu et al

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Tirzepatide, by contrast, activates both glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) receptors simultaneously, producing rapid satiety signaling, improved insulin sensitivity, and accelerated weight reduction