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The DNA methylation clock is a recognized biomarker of aging, and -KG serves as an essential cosubstrate for histone demethylases of the Jumonji C domain-containing family (JMJDs) and for DNA demethylases of the ten-eleven translocation (TET) enzyme family [126]
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Orally administered glutathione is primarily absorbed in the intestine, while circulating glutathione is cleared by the kidneys, which leads to its poor absorption from the gastrointestinal tract
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