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In these studies, small intestine gene expression of ZO-1 and occludin were reduced in mice fed a high-fat diet and distribution altered in ob/ob mice

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[DOI] [PubMed] [Google Scholar] Xia B, Zhou Q, Zheng Z, Ye L, Hu M, and Liu Z (2012) A novel local recycling mechanism that enhances enteric bioavailability of flavonoids and prolongs their residence time in the gut

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A major characteristic of SARS-CoV-2 infection is oxidative stress, which leads to inflammation and vascular dysfunction