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Furthermore, evidence from diabetic rats and cultured mature adipocytes demonstrated that fumarate as an electrophile can directly react with GSH and cysteine residues in proteins via a Michael addition reaction forming S-(2-succinyl)-cysteine (succination), supporting the view that fumarate can irreversibly modify GSH (1, 67)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 9.Murley A., Nunnari J
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