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It works by binding to the ghrelin receptor (GHS-R1a) in the hypothalamus and pituitary, triggering a calcium/PKC signaling cascade that releases stored growth hormone, while separately blunting somatostatin's inhibitory signal

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Resources like SeekPeptides have documented these patterns extensively, providing researchers with tools to navigate nutrient management during GLP-1 therapy

[,] The references of the included studies were manually searched, and no further articles were included

[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Siracusa R., Fusco R., Peritore A.F., Cordaro M., DAmico R., Genovese T., Gugliandolo E., Crupi R., Smeriglio A., Mandalari G., et al

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