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Gradient compression garments meant for daytime (waking) provide a higher level of compression, and use of them while sleeping could cause new or additional damage to the affected tissue

Centers for Disease Control and PreventionOnce opened or first punctured, a multi-dose vial should be dated and discarded within 28 days unless the manufacturer specifies otherwise

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Preparation, Storage, and Consistency Even the best protocol on paper fails if preparation and handling are sloppy

Beyond-use dates and storage conditions must be determined by validated stability data for the specific product, not by general estimates

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