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doi: 10.1016/S1470-2045(14)71133-7

Both AGE-R1 and AGR-R3 participate in the detoxification of AGE, thereby preventing the development of diseases related to AGE-RAGE axis [13, 48]

[DOI] [PubMed] [Google Scholar] 100.Mitchell T., Clarke L., Goldberg A., Bishop K

They also mitigate Nf-B overactivated signalling, attenuating the NLRP3 inflammasome pathway and decreasing pro-inflammatory cytokines and PCR levels, thereby showcasing their immunomodulatory activities [161, 202, 217]

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3 UVB can cause skin cancer by damaging DNA in P53 tumour suppressor genes, which are involved in DNA repair, or by activating genes that promote cancer (oncogenes)
