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Laboratory studies explore optimal administration regimens for different research objectives, including acute versus chronic senescent cell elimination and the effects of repeated administrations on tissue function and aging markers

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Proteolytic digestions of Mpro revealed Cys300 as a primary target of glutathionylation, and experiments using a C300S Mpro mutant revealed that Cys300 is required for inhibition of activity upon Mpro glutathionylation

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