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Possible Adjustments Instead of Stopping: In some cases, your doctor may suggest reducing the dosage or switching to a different form of vitamin B12

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Combination therapies: Orforglipron could be combined with other oral agents (e.g., oral GIP agonists, SGLT-2 inhibitors, phentermine) for enhanced efficacy, or formulated as a fixed-dose combination tablet
Your dose exceeds your syringe capacity

Lagu B, Wu X, Kulkarni S, Paul R, Becherer JD, Olson L, et al

This is called the initial loading phase
