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Adult growth hormone deficiency is a CFS-like disease characterized by tiredness, fatigue, and myalgia, associated with impaired STAT5 signal transduction pathway (Webb et al

[DOI] [PMC free article] [PubMed] [Google Scholar] Arterburn L

Meta-analysis of 10 clinical trials found NAC supplementation reduced depressive symptoms by 26% compared to placebo groups

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This poses significant challenges for the long-term success of gene therapy, mainly in patients receiving low doses of AAV, such as children, as tissue growth and proliferation may dilute the vector genome, potentially worsening symptoms over time