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Integration of AI, particularly through combined learning with multi-omics, spatial omics, histopathological imaging, and other multimodal data, may further improve the accuracy and generalizability of system modeling

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AD pathogenesis downstream of iron-related oxidative damage is driven through changes in Nrf2 signaling To determine whether the outcome of iron-related oxidative damage in AD pathology was due to a dysregulation of iron homeostasis directly or through changes in downstream antioxidant pathways, we next measured changes in major transcriptional regulators of iron and oxidative damage handling